MTAP (RBT-MTAP) -RMab
SKU: MTAP (RBT-MTAP) -RMab
Antibodies are temperature sensitive, and
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Summary and ExplanationThe S-methyl-5′-thioadenosine phosphorylase (MTAP) metabolizes methylthioadenosine (MTA), a byproduct of polyamine synthesis and regulator of protein methylation, to salvage adenine and methionine residues for reuse in many pathways affecting cell proliferation, signaling, and apoptosis. The MTAP gene, located at 9p12.3, is co-deleted with CDKN2A (encodes p16 tumor-suppressor) in several types of cancer and is abundant in all normal tissues but is deficient in various tumors. IHC has been found to be an accurate and useful diagnostic method for detecting MTAP deficiency in NSCLC, and the frequency of MTAP deficiency was found to be relatively high. Accumulated MTA can upregulate transcription factors, activate ERK pathways in Melanoma and MAPK in Liver Cancer causing invasive and metastasizing tumors, and disrupt function of secretory cells in tissues like the prostate. Disrupted DNA methylation affects epigenetic factors and can lead to dedifferentiated stem-like cancer cells in Glioblastoma, although these cells can suffer purine starvation without a functioning salvage pathway. Overexpression of MTAP is also associated with increased proliferation and epithelial-to-mesenchymal transition in Colorectal Carcinoma. A study has found that a combination of MTAP antibody or BAP1 antibody loss detected by IHC can likely detect malignant pleural mesothelioma (MPM) with good sensitivity and 100% specificity, and serve as a useful ancillary IHC for discriminating MPM from reactive mesothelial hyperplasia (RMH).
Presentation DescriptionMTAP is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
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