MSH2 (BSB-147) -RMab
SKU: MSH2 (BSB-147) -RMab
Antibodies are temperature sensitive, and
MUST ship Priority Overnight!
Summary and ExplanationMSH2 is a mouse monoclonal antibody for immunohistochemistry from Bio SB. MSH2 is a mismatch repair gene commonly associated with Hereditary Non-Polyposis Colorectal Cancer (HNPCC). This gene was identified as a locus frequently mutated in HNPCC. When cloned, it is a human homolog of the E. coli DNA mismatch repair gene mutS, consistent with the characteristic alterations in microsatellite sequences (RER+ phenotype) found in HNPCC. MSH2 antibody expression is abnormally deficient in a high proportion of patients with microsatellite instability (MSI-H). This finding is associated with the autosomal dominant condition found in Hereditary Non-Polyposis Colon Cancer. This MSH2 antibody (along with MLH1 antibody) is useful in screening patients and families for this rare condition. Colon cancers that are microsatellite unstable have a better prognosis than their microsatellite stable counterparts.
Presentation DescriptionMSH2 antibody is a mouse monoclonal antibody for immunohistochemistry derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
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