Cytokeratin 5 & 6 (RM341), RMab

SKU: Cytokeratin 5 & 6 (RM341) -RMab
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IgG - RM341

Antibodies are temperature sensitive, and MUST ship Priority Overnight!

Summary and Explanation

Cytokeratin 5 (58 kDa) is a high-molecular weight, basic type of cytokeratin expressed in basal, intermediate and superficial-cell layers of stratified epithelia as well as transitional epithelia, complex epithelia, mesothelial cells and Mesothelioma. Cytokeratin 6 (56 kD) is also a high-molecular weight, basic type cytokeratin expressed by proliferating squamous epithelium often paired with Cytokeratin 16. Cytokeratin 5 & 6 antibody is positively seen in nearly 100% of Malignant Mesotheliomas and are rarely seen in Lung Adenocarcinomas. CK 5 and 6 can positively be seen in undifferentiated Large-cell Carcinoma as well as Squamous Carcinoma. Fewer than 10% of Carcinomas of the breast, colon, and prostate stain positively for this marker. Cytokeratin 5 & 6 antibody has also been used successfully as a myoepithelial cell marker in the prostate to determine malignancy.

Presentation Description

Cytokeratin 5 & 6 is a rabbit monoclonal antibody for immunohistochemistry derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
TypeRMab
CloneRM341
IsotypeIgG
ReactivityParaffin, Frozen
Application
Control

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