SS18-SSX (RBT-SS18-SSX), RMab

Antibodies are temperature sensitive, and MUST ship Priority Overnight!

Summary and Explanation

Expression of SS18-SSX fusion protein is the hallmark of Synovial Sarcoma, a type of soft tissue sarcoma that accounts for 5-10% of all soft tissue sarcoma. Diagnosis of synovial sarcoma can be challenging due to histologic overlap with a range of other tumors, therefore, IHC is routinely used in differential diagnosis. SS18-SSX is a fusion oncoprotein created during chromosome translocation in which the SS18 gene on chromosome 18 is fused to the SSX1, SSX2, or SSX4 gene on the X chromosome. Normally, SS18 subunit and BAF47 subunit bind to BAF (mSWI/SNF) complex which produces polycomb-mediated repression of Sox-2 and cessation of proliferation. SS18-SSX renders the BAF chromatin remodeling complex aberrant through the addition of SSX to the SS18 subunit and the loss of BAF47 subunit from the BAF (mSWI/SNF) complex. The altered complexes reverse the polycomb-mediated repression and result in the activation of Sox-2 and uncontrolled proliferation.

Presentation Description

SS18-SSX is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.

Type	RMab
Clone	RBT-SS18-SSX
Isotype	IgG
Reactivity	Paraffin, Frozen
Application
Control