Beta-Catenin (RM276) -RMab
SKU: Beta-Catenin (RM276) -RMab
Antibodies are temperature sensitive, and
MUST ship Priority Overnight!
Summary and ExplanationBeta-Catenin is a subunit of the Cadherin protein complex. Cadherins are a type of protein normally expressed on the surface of certain cells. Specifically, Beta-Cateinin is a 92 kDa protein normally found in the cytoplasm of the cell in the sub-membranous location. The Beta-Catenin antibody is associated with E-Cadherin and may be essential for the function of E-Cadherin. Mutations in the Beta-Catenin gene result in the nuclear accumulation of this protein. Nuclear accumulation of this protein has been demonstrated in Fibromatosis lesions of the breast and abdomen, and therefore is useful in differentiating this lesion from other spindle-cell lesions that may occur in these locations.
Presentation DescriptionBeta-Catenin is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
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